Warfarin Sensitivity/Resistance SNPs
- Description
- Analysis of SNPs in the VKORC1, CYP2C9 & CYP4F2 genes associated with Warfarin resistance or sensitivity.
- Clinical details
- Some patients show an apparent resistance or sensitivity to Warfarin when started on standard dosing regimes. Individuals with the CYP2C9*2 and CYP2C9*3 genotype show impaired metabolism of warfarin and, therefore, require a lower dose compared to CYP2C9*1 individuals. The T allele for the VKCORC1 1173C>T polymorphism is associated with a lower dose requirement. Individuals homozygous (T/T) for the CYP4F2 450C>T polymorphism show a mild resistance, requiring approximately 1mg/day extra warfarin compared to C/C individuals.
- Related condition
- Reference range
n/a
- Units
- n/a
- Synonyms
- VKORC1 CYP2C9 CYP4F2 Warfarin resistance Warfarin sensitivity
- Testing site
- Synnovis : Genomics : St Thomas' Hospital
- Laboratory
- Molecular Haemostasis
- Sample type and volume required
- 1 x Edta
- Call in advance
- no
- Storage and transport
- transport at ambient temperature
- Turnaround time
- 14 days
- Contacts
Molecular Haemostasis Laboratory at St Thomas’ Hospital
Phone: 020 7188 2798
Haemostasis and Thrombosis
North Wing – 4th floor
St Thomas’ Hospital
Westminster Bridge Road
London SE1 7EH
Laboratory opening times
Monday – Friday 09.00 – 17.00