Vitamin K1
- Description
- Liquid chromatography mass spectrometry (LC-MS/MS) for the determination of Vitamin K1 Due to the relocation of the Nutristasis service to the Blackfriars Hub site, this test is not currently accredited by UKAS to ISO15189
- Clinical details
- Vitamin K is a fat-soluble vitamin with important roles in blood coagulation factor synthesis, bone mineralisation and vascular calcification. There are various forms of vitamin K. Vitamin K1 (phylloquinone) is synthesised by plants, vitamin K2 (the menaquinones) are predominantly of bacterial origin while vitamin K3 (menadione) is a synthetic pharmaceutical. At the Nutristasis unit we assess tissue stores by measuring serum vitamin K1 levels, from which it is possible to identify suboptimal status before the appearance of symptoms. In addition to vitamin K1 we also measure undercarboxylated prothrombin (PIVKA-II) to provide additional insight in to the nature and extent of the deficiency. PIVKA-II can also help investigate cases where vitamin K antagonists are involved or complications due to poor hepatic function. Screening for vitamin K deficiency is recommended in high risk groups such as those with malnutrition, malabsorption (e.g. cystic fibrosis, short bowel, Crohn's disease, biliary problems etc) or those who may have impaired utilisation of vitamin K e.g. liver disease.
- Related condition
- Reference range
0.15-1.55 ug/L
- Units
- ug/L
- Synonyms
- Phylloquinone, menaquinone, menadione, phytomenadione
- Testing site
- Synnovis : Reference Services : Blackfriars Hub
- Laboratory
- Nutristasis Unit
- Sample type and volume required
- Separated serum - 0.5mL
- Call in advance
- No
- Special sample instructions
Protect from light.
Whole blood unsuitable.
- Storage and transport
- Sample must be protected from light
- Turnaround time
- 10 days
- Patient description
- Vitamin K is a fat-soluble vitamin with important roles in blood coagulation factor synthesis, bone mineralisation and vascular calcification. There are various forms of vitamin K. Vitamin K1 (phylloquinone) is synthesised by plants, vitamin K2 (the menaquinones) are predominantly of bacterial origin while vitamin K3 (menadione) is employed as a pharmaceutical. At the Nutristasis unit we assess tissue stores by measuring serum vitamin K1 levels, from which it is possible to identify suboptimal status before the appearance of symptoms. In addition to vitamin K1 we also measure undercarboxylated prothrombin (PIVKA-II) to provide additional insight in to the nature and extent of the deficiency. PIVKA-II can also help investigate cases where vitamin K antagonists are involved or complications due to poor hepatic function. Screening for vitamin K deficiency is recommended in high risk groups such as those with malnutrition, malabsorption (e.g. cystic fibrosis, short bowel, Crohn's disease, biliary problems etc) or those who may have impaired utilisation of vitamin K e.g. liver disease. Vitamin K1 is measured by reversed phase HPLC with post column in-line chemical reduction and fluorescence detection.
- Contacts
Nutristasis Unit at Blackfriars Hub
Phone: 0204 591 0055
Email: Nutristasis@synnovis.co.uk
Nutristasis
Floor 1, Synnovis Hub
Friars Bridge Court
41-43 Blackfriars Road
London
SE1 8NZ