Available tests
Karyotyping
Fluorescence in situ hybridisation: BCR-ABL to detect episomal amplification of ABL; MLL to detect 11q23 rearrangement
Clinical details
Cytogenetic analysis in T-cell acute lymphoblastic leukaemia (T-ALL) can aid in the diagnosis of disease and identify markers which can then be used to assess remission status and in disease monitoring. T-ALL FISH testing strategy:
Synonyms
T-ALL, T-cell ALL, T-cell acute lymphoblastic leukaemia, BCR-ABL, NUP214/ABL, MLL
Testing site
Synnovis : Genomics : Guy's Hospital
Laboratory
Cancer Genetics
Sample type and volume required
Peripheral blood, bone marrow aspirate, pleural effusion, fine needle aspirate, as appropriate, minimum volume as available
Storage and transport
Peripheral blood in lithium heparin or bone marrow transport medium. All other samples in bone marrow transport medium. Do not spindown or freeze samples beforesending. Samples must arrive within 24 hours
Turnaround time
Current service turnaround times: Urgent 1-7 calendar days; Non-urgent 5-10 calendar days; National targets: Urgent samples 95% reported within 14 days; Non-urgent 95% reported within 21 days
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