Protein S100B
- Description
- Tumour Marker: Protein S100B in serum or CSF measured by a chemiluminescent method on the Liaison analyser (DiaSorin).
- Clinical details
- Protein S100B is a member of a family of calcium binding proteins. S100B is present in astrocytes and glial cells in the brain and also in melanocytes. Protein S100B is currently being used in monitoring patients with malignant melanoma. Whilst the diagnosis of melanoma uses a combination of clinical and histological features, detection of metastases can be more difficult. A value greater than 0.2 µg/L is indicative of advanced disease (Stages 3 and 4) with a Positive Predictive Value of approximately 90%. Rising values can be seen 1-2 months in advance of clinical features of metastatic disease. The plasma concentration of S100B has been shown to be related to tumour burden and gives an early indication of successful response to chemotherapy. Values that fail to fall after one month of chemotherapy indicate the tumour is insensitive to the particular chemotherapy regime. S100B is also a biochemical marker of brain injury and and a number of studies have been carried out to investigate its role in assessing and monitoring of closed head injuries and stokes.
- Related condition
- Reference range
The normal range for serum S100B is < 0.2 µg/L
- Synonyms
- S100B, s100b, s100
- Testing site
- Synnovis : Reference Services : King's College Hospital
- Laboratory
- Immunochemistry
- Sample type and volume required
- Serum (250 µL). Should be separated from red cells within 2-4 hours.
- Storage and transport
- Must be sent frozen by courier.
- Turnaround time
- Within 7 working days.
- Contacts
Immunochemistry Laboratory at Blackfriars Hub
Phone: 020 8078 8984
Immunochemistry Laboratory
Floor 1, Synnovis hub
Friars Bridge Court
41-43 Blackfriars Road
London, SE1 8NZReference Biochemistry Department at King’s College Hospital
Phone: 020 3299 4107
King’s College Hospital
Denmark Hill
London SE5 9RS