LKM1 blot (Part of liver immunoblot panel)
- Description
- Part of Liver immunoblot panel, includes M2, LKM, LC-1 and SLA antibodies. Antibodies to liver and kidney microsomes are characteristically associated with Type 2 autoimmune hepatitis. They may develop transiently after viral hepatitis. The antibody is tested for by IIF using a rodent composite block of liver, kidney and stomach. Sub-types of anti-LKM have been described, anti-LKM 1, 2 and 3, based on the IIF staining pattern. It can be difficult to detect in the presence of anti-gastric parietal cell antibody and requires experience to be able distinguish these patterns. The laboratory routinely reports anti-LKM 1 antibodies and this done after confirmation by autoimmune liver blot and a titre result issued.
- Reference range
Negative / positive.
- Units
- Negative - equivocal - positive
- Testing site
- Synnovis : Reference Services : Blackfriars Hub
- Laboratory
- Diagnostic Immunology
- Sample type and volume required
- Clotted (Gold top vacutainer)
- Special sample instructions
All tests are compromised by prolonged transit times. For this reason, date of bleed and date of postage must be provided with each request.
- Storage and transport
- Samples may be stored at 4°C prior to despatch. The use of first class letter post without the need for coolant is sufficient.
- Turnaround time
- 6 days
- Time limit for extra tests
- 10 days