Haemoglobinopathy Screen
- Description
- The haemoglobinopathy screen by HPLC is used in conjuction with clinical details and results of the FBC to identify Haemoglobin variants and thalassaemias. All Hb variants detected are confirmed by a secondary method. This screen is commonly used in antenatal screening, pre-operative screening and to provide HbS% for transfused sickle cell patients.
- Clinical details
- Screen for haemoglobin variants and thalassaemias
- Related condition
- Reference range
HbA2 1.8 - 3.4% of total Hb (adults only). HbF ≤1.5% of total Hb (adults only)
- Synonyms
- Sickle test, HbS%, Hb electrophoresis, haemoglobin electrophoresis, thalassaemia screen, SICK, HPLC, haemoglobinopathy, variant identification, sickle, antenatal screen
- Testing site
- Synnovis : Blood Sciences : Guy's Hospital
- Laboratory
- Red Cell
- Sample type and volume required
- Whole blood in EDTA. Required volume is variable as secondary testing may be required. The minimum acceptable volume of whole blood is 1mL.
- Special sample instructions
Referred in samples must be fully labelled and accompanied with a completed referral request form. A copy of the referral form can be located in the FURTHER INFO tab. Please provide the FBC result, antenatal status and family origins.
- Storage and transport
- Blood should be stored at 4°C where possible and may be transported at ambient temperature.
- Turnaround time
- 3 working days
- Contacts
Special Haematology Department St Thomas’ Hospital
Phone – 020 7188 8189
St Thomas’ Hospital
5th Floor – North Wing
Westminster Bridge Road
London SE1 7EHSpecial Haematology Department at Guy’s Hospital
Phone – 020 7188 3421
Guy’s Hospital
4th Floor – Southwark Wing
Great Maze Pond
London SE1 9RTRed Cell Centre – Protein Laboratory
Phone: 020 3299 2455
Email: kch-tr.redcelllab@nhs.net
Central Specimen Reception
Blood Sciences Laboratory
Ground Floor Bessemer Wing
King’s College Hospital
Denmark Hill
London SE5 9RS