Autoantibodies to double stranded DNA (dsDNA) are one of many autoantibodies to nuclear related antigens. They are of particular significance in the diagnosis and management of systemic lupus erythematosus (SLE) where there is evidence that the titre of the antibody is related to disease activity and useful in monitoring treatment. In drug induced lupus anti-dsDNA is usually negative. The antigen used in this ELISA assay is a human recombinant dsDNA.
Related condition
SLE
Reference range
<10
Units
IU/ml
Testing site
Synnovis : Reference Services : Blackfriars Hub
Laboratory
Diagnostic Immunology
Sample type and volume required
Clotted (Gold top vacutainer) 4 ml
Special sample instructions
All tests are compromised by prolonged transit times. For this reason, date of bleed and date of postage must be provided with each request.
Storage and transport
Serum stored at 4°C should be sent by first class post
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