Beta-2 Transferrin/Tau Protein
- Description
- Beta-2-transferrin (Tau protein) in CSF detected by isoelectric focusing
- Clinical details
Beta-2 transferrin also known as Tau protein is the carbohydrate free isoform of transferrin. It is produced from transferrin by loss of sialic acid due to the presence of neuraminidase activity in the brain; therefore, beta-2 transferrin is located only within the cerebrospinal fluid (CSF), perilymph, and aqueous humor. Its absence from other bodily secretions makes its detection invaluable in confirming the *diagnosis of CSF rhinorrhea or otorrhea* (leakage of CSF into the nose or ear canal, usually as a result of head trauma, tumor, congenital malformation or surgery).
- Testing site
- Synnovis : Reference Services : Blackfriars Hub
- Laboratory
- Immunochemistry
- Sample type and volume required
Collect fluid samples in a plain or glass tube, centrifuge the sample and aliquot (minimum volume required for analysis is 50 µL). If possible please provide us with a matched serum sample (50 µL).
- Storage and transport
Samples from external laboratories can be sent to us by first class post.
- Turnaround time
2 working days
- Contacts
Immunochemistry Laboratory at Blackfriars Hub
Phone: 020 8078 8984
Immunochemistry Laboratory
Floor 1, Synnovis hub
Friars Bridge Court
41-43 Blackfriars Road
London, SE1 8NZ