Interphase fluorescence in situ hybridisation for: TP53(17p13.1) deletion; ATM (11q22.3) deletion;
DLEU(13q14)/LAMP(13q34) to detect del(13q); CEP12 to detect trisomy 12
Clinical details
Cytogenetic abnormalities detected by interphase FISH analysis are well-established prognostic markers in patients with a known diagnosis of B-cell chronic lymphocytic leukaemia (B-CLL).
Peripheral blood, bone marrow aspirate, as appropriate, minimum volume as available
Storage and transport
Peripheral blood in lithium heparin or bone marrow transport medium. All other samples in bone marrow transport medium. Do not spindown or freeze samples before sending. Samples must arrive within 24 hours
Turnaround time
Current service turnaround times: Urgent 1-7 calendar days; Non-urgent 5-10 calendar days; National targets: Urgent samples 95% reported within 14 days; Non-urgent 95% reported within 21 days
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