Allopurinol adherence monitoring (urine)
- Description
- Allopurinol is a xanthine oxidase inhibitor used in the treatment of gout. Levels of allopurinol and oxypurinol in urine are useful for confirming adherence.
- Clinical details
Monitoring adherence in patients treated for gout, HPRT deficiency or APRT deficiency. The test also measures urinary purine levels. In patients with purine overproduction due to HPRT deficiency, levels of insoluble xanthine in urine should be monitored, and if above the limit of solubility, the dose of allopurinol reduced to minimise the risk of a xanthine nephropathy. Allopurinol is also used in the treatment of APRT deficiency to prevent the formation of insoluble 2,8-dihydroxyadenine.
- Related condition
- Reference range
Please contact thelaboratory to discuss
- Units
Urine in universal container containing thymol (10 ml required)
- Testing site
- Synnovis : Reference Services : Blackfriars Hub
- Laboratory
- Inherited Metabolic Disease
- Sample type and volume required
24 hr urine bottle/Universal container containing thymol
- Storage and transport
store in fridge (short term )or freezer, can thaw in 1st class post
- Turnaround time
3 weeks
- Contacts
Inherited Metabolic Diseases Unit at Blackfriars Hub
Phone: 020 4591 0070
IMD Duty Biochemist: 07592 502653
Email: ClinicalScientistIMD@synnovis.co.uk
Reference Chemistry
Floor 1, Synnovis hub
Friars Bridge Court
41-43 Blackfriars Road
London
SE1 8NZ