Aldosterone/Renin
- Description
- Renin and aldosterone assayed by chemiluminescent immunoassay using the Diasorin Liaison
- Clinical details
The renin-angiotensin-aldosterone axis plays a vital role in sodium homeostasis and maintenance of blood volume and pressure. Disorders of the renin-angiotensin-aldosterone axis can lead to major metabolic imbalances and disease. Renin, aldosterone and their ratio are the most frequently measured parameters used to assess renin-angiotensin-aldosterone axis integrity.
Assessment of the renin-angiotensin-aldosterone axis has assumed a much greater role in clinical practice, particularly in the evaluation of patients with hypertension.
In addition, the axis is often evaluated in patients with:
– Hypo or hyperkalaemia who may have hyperaldosteronism (or other forms of genuine or apparent mineralocorticoid excess) or hypoaldosteronism respectively.
– Adrenal insufficiency – to distinguish primary from secondary cause.
- Reference range
Renin (mU/L): Upright 5.4 – 60, Supine 5.4 – 30
Aldosterone (pmol/L): Upright 100 – 800, Supine 100 – 450
Aldo/Renin ratio: <80: Conn’s unlikely, >/=200: Conn’s likely, 80-200: Conn’s not excluded
- Testing site
- Synnovis : Reference Services : Blackfriars Hub
- Laboratory
- Immunochemistry
- Sample type and volume required
EDTA Plasma – Plasma must be separated from cells immediately after centrifugation with a minimum volume of 1ml aliquoted into an appropriate tube. Store at -20ºC until transport.
- Call in advance
No
- Storage and transport
Must be sent frozen by courier.
Address specimens to: Department of Clinical Biochemistry, Bessemer Wing, King’s College Hospital, Denmark Hill, London SE5 9RS
- Turnaround time
Results within 7-10 working days
- Contacts
Immunochemistry Laboratory at Blackfriars Hub
Phone: 020 8078 8984
Immunochemistry Laboratory
Floor 1, Synnovis hub
Friars Bridge Court
41-43 Blackfriars Road
London, SE1 8NZ