Test Database

Description

Measurement of 11-Deoxycortisol is used in the diagnosis and management of patients with congenital adrenal hyperplasia due to 11-hydroxylase deficiency. It is also used to assess the adrenal response to metyrapone in patients with Cushing's syndrome. Please note, method of analysis is LC-MS/MS.

Clinical details

Measurement of 11-Deoxycortisol is used in: 1) Diagnosis of and monitoring therapeutic response in, congenital adrenal hyperplasia due to 11 -hydroxylase deficiency. 11-Deoxycortisol accumulates in the peripheral circulation when there is a deficiency of 11 -hydroxylase activity. 11-Deoxycortisol should be measured when congenital adrenal hyperplasia is suspected on clinical grounds but serum 17-hydroxyprogesterone values are equivocal. 2) Assessment of adrenal response in the metyrapone test. Metyrapone is an inhibitor of 11 -hydroxylase activity. In the differential diagnosis of Cushing's syndrome, metyrapone is given and subsequent changes in serum concentrations of 11-deoxycortisol provide strong (but not absolute) indicators of the site of the primary lesion.

Related condition

Congenital adrenal hyperplasia (11-hydroxylase deficiency), Cushing's syndrome, Metyrapone test.

Reference range

Adult reference range 0.7 - 2.7 nmol/L. No specific paediatric reference range quoted, however each result will have interpretative comments. Please contact the laboratory if you wish to discuss.

Units

nmol/L

Synonyms

11-Deoxycortisol, Deoxycortisol

Testing site

Synnovis : Reference Services : Blackfriars Hub

Laboratory

Steroid