Haemoglobinopathy Screen
- Description
- The haemoglobinopathy screen by HPLC is used in conjuction with clinical details and results of the FBC to identify Haemoglobin variants and thalassaemias. All Hb variants detected are confirmed by a secondary method. This screen is commonly used in antenatal screening, pre-operative screening and to provide HbS% for transfused sickle cell patients.
- Clinical details
Screen for haemoglobin variants and thalassaemias
- Related condition
- Reference range
HbA2 1.8 – 3.4% of total Hb (adults only). HbF ≤1.5% of total Hb (adults only)
- Synonyms
Sickle test, HbS%, Hb electrophoresis, haemoglobin electrophoresis, thalassaemia screen, SICK, HPLC, haemoglobinopathy, variant identification, sickle, antenatal screen
- Testing site
- Synnovis : Blood Sciences : Blackfriars Hub
- Laboratory
- Red Cell
- Sample type and volume required
Whole blood in EDTA. Required volume is variable as secondary testing may be required. The minimum acceptable volume of whole blood is 1mL.
- Special sample instructions
Referred in samples must be fully labelled and accompanied with a completed referral request form. A copy of the referral form can be located in the FURTHER INFO tab. Please provide the FBC result, antenatal status and family origins.
- Storage and transport
Blood should be stored at 4°C where possible and may be transported at ambient temperature.
- Turnaround time
3 working days
- Contacts
Specialist Red Cell Laboratory
Phone – 020 4591 0045
Synnovis Hub
Floor 2
Friars Bridge Court
41-43 Blackfriars Road
London SE1 8NZ