VKORC1 mutation screen
- Description
- Analysis of the VKORC1 gene by PCR amplification and sequencing of the coding region and splice junctions.
- Clinical details
- Warfarin Resistance can be a significant clinical problem and may be due to drug, diet or compliance issues or may be genetic. The major cause of true hereditary warfarin resistance are mutations in the VKORC1 gene - polymorphisms in VKORC1 and cytochrome genes e.g. CYP2C9 may cause mild resistance. Analysis of VKORC1 is appropriate in patients showing significant resistance to warfarin dosing. Mutations in VKORC1 have also been associated with warfarin sensitivity.
- Related condition
- Reference range
n/a
- Units
- n/a
- Synonyms
- Vitamin K epoxide reductase complex subunit 1. VKORC1 Warfarin resistance Warfarin sensitivity
- Testing site
- Synnovis : Genomics : St Thomas' Hospital
- Laboratory
- Molecular Haemostasis
- Sample type and volume required
- 1 x Edta
- Call in advance
- no
- Storage and transport
- transport at ambient temperature
- Turnaround time
- 4 weeks
- Contacts
Molecular Haemostasis Laboratory at St Thomas’ Hospital
Phone: 020 7188 2798
Haemostasis and Thrombosis
North Wing – 4th floor
St Thomas’ Hospital
Westminster Bridge Road
London SE1 7EH
Laboratory opening times
Monday – Friday 09.00 – 17.00