Total urine porphyrins (TUP)
- Description
- TUP is a test offered by the SAAS Porphyria Service in Reference Biochemistry at King's College Hospital. Quantitative measurement of TUP is carried out using spectrophotometry.
- Clinical details
- Porphyrins are precursors in the haem synthesis pathway and TUP can be elevated in patients during an acute porphyria attack and in patients with the cutaneous porphyrias e.g. congenital erythropoietic porphyria (CEP) and porphyria cutanea tarda (PCT).
- Related condition
- Reference range
Random urine < 35 nmol/mmol creatinine
- Synonyms
- TUP
- Testing site
- Synnovis : Reference Services : King's College Hospital
- Laboratory
- Porphyrins and Gastrointestinal
- Sample type and volume required
- 10 - 20 mL fresh urine, preferably collected early morning. No preservative is necessary but specimens should be protected from light.
- Storage and transport
- Specimens can be sent by first class post without ice packs. Specimens are stable for several weeks if frozen while awaiting despatch.
- Turnaround time
- 1-2 weeks
- Contacts
Porphyrin Laboratory at Blackfriars Hub
Phone: 0208 078 8996
Email: PorphyrinLab@synnovis.co.uk
Porphyrin Laboratory
Floor 1, Synnovis hub
Friars Bridge Court
41-43 Blackfriars Road
London, SE1 8NZ