Elevated concentrations of serum tryptase are found in patients with mastocytosis, in anaphylaxis and other direct mast cell degranulation events. The assay measures both alpha and beta subunits of tryptase. The investigation of suspected anaphylaxis requires that 3 blood samples are taken;
1) As soon as possible after onset of anaphylaxis, within one hour
2) Between 3 and 6 hours post-anaphylaxis
3) At least 24 hours after onset
This timescale allows the differentiation of true anaphylaxis and mastocytosis. In anaphylaxis the tryptase concentration will return to baseline post 24 hours whereas in mastocytosis the concentration remains high.
Related condition
Allergic reaction
Reference range
41671
Units
ug/L
Testing site
Synnovis : Reference Services : Blackfriars Hub
Laboratory
Diagnostic Immunology
Sample type and volume required
Clotted (Gold top vacutainer)
Special sample instructions
All tests are compromised by long transit times. For this reason the date of bleed and of postage must be provided with each request. This is an absolute requirement in the case of suspected anaphylaxis.
Storage and transport
Serum stored at 4°C should be sent by first class post as soon as possible.
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