Serum Free Kappa and Lambda Light Chains (SFLC)
- Description
- Serum free light chain analysis by enzyme immunoassay
- Clinical details
- Serum capillary electrophoresis may not detect all paraproteins due to factors like low concentration, inadequate electrophoretic separation or being present only in urine. In such instances quantifying serum free kappa and lambda light chains, calculating the κ:λ ratio and urine protein electrophoresis may help identify monoclonal proteins. The κ:λ ratio may be abnormal in amyloidosis, light chain disease and in impaired renal function.
- Related condition
- Reference range
Free kappa light chains 3.30 - 19.40 Free lambda light chains 5.71 - 26.30 Kappa/Lambda ratio 0.26 - 1.65
- Units
- mg/L
- Testing site
- Synnovis : Reference Services : Blackfriars Hub
- Laboratory
- Diagnostic Immunology
- Sample type and volume required
- Clotted (Gold top vacutainer)
- Special sample instructions
All tests are compromised by prolonged transit times. For this reason, date of bleed and date of postage must be provided with each request.
- Storage and transport
- Please contact laboratory if urgent analysis is required. Serum stored at 4°C should be sent by first class post
- Turnaround time
- 3 working days
- Time limit for extra tests
- 10 days