PT20210G>A polymorphism
- Description
- Direct detection of F2 c.*97G>A (PT20210G>A) polymorphism.
- Clinical details
- The PT20210G>A polymorphism in the 3'UTR of the F2 gene is associated with raised plasma prothrombin levels and is a risk factor for venous thrombosis. It is found in ~1-2% of caucasians (more common in those of southern european descent) but is uncommon in other populations. Heterozygosity is associated with an approximately 3-fold increased risk of thrombosis and it is identified in ~6-8% of thrombophilia patients. Homozygosity is rare, ~1 in 10,000, so the relative risk of thrombosis is difficult to calculate.
- Related condition
- Reference range
n/a
- Units
- n/a
- Synonyms
- PT20210 F2 Leiden (FII Leiden) Thrombophilia risk factor
- Testing site
- Synnovis : Genomics : St Thomas' Hospital
- Laboratory
- Molecular Haemostasis
- Sample type and volume required
- 1 x Edta
- Call in advance
- no
- Storage and transport
- transport at ambient temperature
- Turnaround time
- 7 days
- Contacts
Molecular Haemostasis Laboratory at St Thomas’ Hospital
Phone: 020 7188 2798
Haemostasis and Thrombosis
North Wing – 4th floor
St Thomas’ Hospital
Westminster Bridge Road
London SE1 7EH
Laboratory opening times
Monday – Friday 09.00 – 17.00