PAI-1 4G/5G Promoter Polymorphism
- Description
- Direct detection of a single base deletion at nucleotide -675 (4G/5G) in the promoter of the PAI-1 (SERPINE1) gene.
- Clinical details
- The presence of the single base deletion (4G/5G or 4G/4G) results in elevated levels of PAI-1 protein which can suppress fibrinolysis. Some studies have associated the 4G allele with an increased risk of thrombosis, MI, fetal loss and pre-eclampsia, although other studies dispute this. It is probable that only homozygosity (4G/4G) has any significance.
- Related condition
- Reference range
n/a
- Units
- n/a
- Synonyms
- PAI-1 SERPINE1 4G/5G
- Testing site
- Synnovis : Genomics : St Thomas' Hospital
- Laboratory
- Molecular Haemostasis
- Sample type and volume required
- 1 x Edta
- Call in advance
- no
- Storage and transport
- transport at ambient temperature
- Turnaround time
- 14 days
- Contacts
Molecular Haemostasis Laboratory at St Thomas’ Hospital
Phone: 020 7188 2798
Haemostasis and Thrombosis
North Wing – 4th floor
St Thomas’ Hospital
Westminster Bridge Road
London SE1 7EH
Laboratory opening times
Monday – Friday 09.00 – 17.00