Mitochondrial antibodies are associated with primary biliary cirrhosis. They can be detected by IIF on a composite rodent block of mouse liver kidney and stomach. A number of different mitochondrial antibodies have been described in association with different hepatic and non-hepatic disorders. The antigenic specificities of some of the mitochondrial antibodies have been identified. The M2 antibody reacts with 2-oxo-acid dehydrogenase complex and is positive in up to 90% of primary biliary cirrhosis but may occur in other chronic liver diseases and systemic sclerosis. If clinically indicated a positive mitochondrial antibody is confirmed by a liver immunoblot.
Related condition
Primary biliary cirrhosis
Reference range
Negative, positives confirmed by titre and immunoblot
Units
Titre, numerical value
Testing site
Synnovis : Reference Services : Blackfriars Hub
Laboratory
Diagnostic Immunology
Sample type and volume required
Clotted (Gold top vacutainer)
Special sample instructions
All tests are compromised by prolonged transit times. For this reason, date of bleed and date of postage must be provided with each request.
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