Manganese
- Description
- Manganese by ICP-MS
- Clinical details
- Manganese is an essential trace element that acts as a catalyst for several enzymes involved in carbohydrate, glycosaminoglycan, and cholesterol metabolism. Manganese superoxide dismutase is found in mitochondria and is responsible for the inactivation of superoxide radicals. Deficiency of manganese may manifest as dermatitis with reduced cholesterol levels in males, although manganese deficiency in clinical practice is rare. Manganese intoxication results in a neurotoxic syndrome known as manganism and is a complication of total parenteral nutrition in those patients with hepatobillary disease. Whole blood is the sample of choice for the measurement of manganese although plasma manganese can also be measured. As manganese is present in the steel used to make cannulas, it is advisable to collect a blood sample for manganese after another sample has been taken, or to discard the first 5 millilitres of blood before collection for manganese measurement. Alternatively a plastic cannula can be used.
- Reference range
Blood Manganese: Children < 1yr : 120-325 nmol/L,
Children > 1 yr/Adults : 73-210 nmol/L
Risk of Toxicity : >360 nmol/L
Serum/plasma Manganese: 9-24 nmol/L,
Urine Manganese: 2-27 nmol/L
- Synonyms
- Manganese, serum/plasma, blood, urine
- Testing site
- Synnovis : Reference Services : King's College Hospital
- Laboratory
- Trace Elements
- Sample type and volume required
- 1ml plasma/serum from Trace element free (royal blue top tube). Whole blood EDTA 20 ml urine (Portion of 24 hour collection [acid-washed bottle] in sterile universal, record total volume on sample tube or request form). Random urine collection in 25ml Sterilin Universal containers.
- Call in advance
- No
- Special sample instructions
Separate serum/plasma as soon as possible after collection.
Transfer to metal-free aliquot tube. Do not transfer serum/plasma in tube with black O-ring.
- Storage and transport
- Stable at 4°C. Send by overnight first class post.
- Turnaround time
- 10 working days for blood, serum/plasma and urine
- Contacts
Toxicology Department at King’s Hospital
Phone: 020 3299 5881
Email: kch-tr.toxicology@nhs.net
King’s College Hospital
Bessemer Wing – 3rd Floor
Denmark Hill
London SE5 9RSTrace Elements Laboratory at King’s College Hospital
Phone: 020 3299 3008
Email: kishor.raja@nhs.net
King’s College Hospital
Bessemer Wing – Top Floor
Denmark Hill
London SE5 9RS