Antibodies to liver and kidney microsomes are characteristically associated with Type 2 autoimmune hepatitis. They may develop transiently after viral hepatitis. The antibody is tested for by IIF using a rodent composite block of liver, kidney and stomach. Sub-types of anti-LKM have been described, anti-LKM 1, 2 and 3, based on the IIF staining pattern. It can be difficult to detect in the presence of anti-gastric parietal cell antibody and requires experience to be able distinguish these patterns. The laboratory routinely reports anti-LKM 1 antibodies and this done after confirmation by autoimmune liver blot and a titre result issued.
Related condition
Autoimmune hepatitis
Reference range
GPC - (Negative / Positive)
ASM, (Negative / Confirmed with titre)
LKM and MITO, (Negative / To confirm)
Units
MITO and LKM confirmed with titre liver blot,
ASM confirmed with titre value,
GPC, (N/A)
Testing site
Synnovis : Reference Services : Blackfriars Hub
Laboratory
Diagnostic Immunology
Sample type and volume required
Clotted (Gold top vacutainer)
Special sample instructions
All tests are compromised by prolonged transit times. For this reason, date of bleed and date of postage must be provided with each request.
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