Liver Cytosol 1 blot (Part of autoimmune liver blot panel)
- Description
- Anti-liver cytosol 1 (anti-LC 1) is associated with type 2 autoimmune hepatitis (AIH). The molecular target of anti-LC 1 is the enzyme formiminotransferase-cyclodeaminase. This autoantibody may be difficult to detect in conventional indirect immunofluorescence especially in the presence of anti-liver kidney microsomal (LKM) antibody 1, the more commonly seen marker of type 2 AIH. Anti-LC1 may occur in the absence of anti-LKM 1 and if type 2 AIH is suspected anti-LC 1 should be requested.
- Related condition
- Reference range
- Negative / Positive
- Units
- Negative / Positive / Equivocal
- Testing site
- Synnovis : Reference Services : Blackfriars Hub
- Laboratory
- Diagnostic Immunology
- Sample type and volume required
- Clotted (Gold top vacutainer)
- Special sample instructions
All tests are compromised by prolonged transit times. For this reason, date of bleed and date of postage must be provided with each request.
- Storage and transport
- Samples may be stored at 4°C prior to despatch. The use of first class letter post without the need for coolant is sufficient.
- Turnaround time
- 6 working days
- Time limit for extra tests
- 10 days