Fractionated urine porphyrins
- Description
- Fractionated urine porphyrins is a test offered by the SAAS Porphyria Service in Reference Biochemistry at King's College Hospital. Quantitative measurement of porphyrins and isomers is carried out using HPLC analysis.
- Clinical details
- Fractionation of porphyrins by HPLC is carried out when the total urine porphyrins (TUP) is above the normal reference range to aid in the differential diagnosis of porphyria and secondary causes of raised TUP associated with liver disorders, excess alcohol consumption and lead toxicity.
- Reference range
(nmol/L)
Total Uroporphyrin (I + II) <24
Heptacarboxylate porphyrin <4
Total Coproporphyrin (I + III) <115
- Testing site
- Synnovis : Reference Services : King's College Hospital
- Laboratory
- Porphyrins and Gastrointestinal
- Sample type and volume required
- 10 - 20 mL fresh urine, preferably collected early morning. No preservative is necessary but specimens should be protected from light
- Storage and transport
- Specimens can be sent by first class post without ice packs. Specimens are stable for several weeks if frozen while awaiting despatch.
- Turnaround time
- 2-3 weeks
- Contacts
Porphyrin Laboratory at Blackfriars Hub
Phone: 0208 078 8996
Email: PorphyrinLab@synnovis.co.uk
Porphyrin Laboratory
Floor 1, Synnovis hub
Friars Bridge Court
41-43 Blackfriars Road
London, SE1 8NZ