Fractionated faecal porphyrins
- Description
- Fractionated faecal porphyrins is a test offered by the SAAS Porphyria Service in Reference Biochemistry at King's College Hospital. Quantitative measurement of porphyrins and isomers is carried out using HPLC analysis.
- Clinical details
- Fractionation by HPLC is carried out when the total faecal porphyrins (TFP) is above the normal reference range to aid in the differentiation between the different types of porphyrias and secondary causes due to dietary causes or increased bacterial degradation of haem in the gut to protoporphyrin and dicarboxylate porphyrins.
- Reference range
Total coproporphyrin (I + III) = <46 nmol/g dry wt, Dicarboxylate porphyrin = <134 nmol/g dry wt
- Testing site
- Synnovis : Reference Services : King's College Hospital
- Laboratory
- Porphyrins and Gastrointestinal
- Sample type and volume required
- ~10 g stool specimen in a plain universal container. Specimens should be protected from light.
- Storage and transport
- Specimens can be sent by first class post without ice packs. Specimens are stable for several weeks if frozen while awaiting despatch.
- Turnaround time
- 2-3 weeks
- Contacts
Porphyrin Laboratory at Blackfriars Hub
Phone: 0208 078 8996
Email: PorphyrinLab@synnovis.co.uk
Porphyrin Laboratory
Floor 1, Synnovis hub
Friars Bridge Court
41-43 Blackfriars Road
London, SE1 8NZ