Test Database

Direct immunofluorescence of skin and mucosal biopsies for autoimmune bullous disease antibodies

Description
Direct immunofluorescence (DIF) is performed on frozen sections prepared from epithelial biopsies, to detect auto-antibodies associated with immunobullous diseases. In addition to skin antibodies, those in mucosal tissue, including oral mucosa and conjunctiva can also be detected. Standard panel fluorescent conjugates are IgM, IgG, IgA, C3c and fibrinogen.
Related condition

Pemphigus vulgaris, pemphigus foliaceus, paraneoplastic pemphigus, IgA pemphigus, bullous pemphigoid, mucous membrane pemphigoid, pemphigoid gestationis, linear IgA bullous dermatosis, epidermolysis bullosa acquisita, dermatitis herpetiformis, systemic lupus erythematosus, discoid lupus erythematosus, lichen planus, IgA vasculitis.

Testing site
Synnovis : Tissue Sciences : St Thomas' Hospital
Laboratory
Immunodermatology
Sample type and volume required

Biopsies must be received in Michel’s medium (supplied by lab)

Turnaround time

5 working days

Contacts

Immunodermatology Laboratory at St Thomas’
Phone: 020 7188 6364
Email: immunodermatology@synnovis.co.uk
St John’s Institute of Dermatology
St Thomas’ Hospital
Westminster Bridge Road
London SE1 7EH
Opening hours: Mon-Fri, 09:00 -17:00

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