Test Database

Description

CXCL10 is a pro-inflammatory cytokine secreted in response to IFN-γ by a variety of cells. Binding of CXCL10 to its receptor, CXCR3, promotes the migration of T cells and monocytes, regulating the immune response. CXCL10 is a biomarker of T cell activity.

Clinical details

In many inflammatory diseases, immune system dysfunction causes CXCL10 to be raised resulting in inflammation. CXCL10 has been shown to be raised in inflammatory disease, such as type 1 diabetes, rheumatoid arthritis, cryoglobulinaemia, SLE, Sjögren's syndrome, and Behçet's Disease. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new strain of coronavirus which causes the coronavirus disease known as COVID-19 7. Severe fever and pneumonia leading to “cytokine storm” causes acute respiratory distress syndrome (ARDS) in approximately 20% of patients and is associated with severe disease. Circulating CXCL10 has been shown to be raised in COVID-19, suggesting T cell activation. Raised CXCL10 is associated with disease severity and has been suggested as a biomarker of COVID-19 severity and outcome.

Reference range

38 - 361

Units

pg/mL

Synonyms

IP10, Covid-19

Testing site

Synnovis : Reference Services : Blackfriars Hub

Laboratory

Diagnostic Immunology