Vitamin K1 2,3- epoxide
- Description
- Liquid chromatography mass spectrometry (LC-MS/MS) for the determination of Vitamin K1 Due to the relocation of the Nutristasis service to the Blackfriars Hub site, this test is not currently accredited by UKAS to ISO15189
- Clinical details
- Vitamin K1 2,3-epoxide is the bi-product of vitamin K1 formed when vitamin K is used as a cofactor in protein modification. Normally vitamin K epoxide is rapidly recycled by the enzyme vitamin K epoxide reductase (VKOR) and is not normally detectable in blood. If the action of the VKOR enzyme is blocked by vitamin K antagonist type anticoagulants such as warfarin or rodenticide superwarfarins vitamin K1 2,3-epoxide accumulates and becomes detectable in the blood.
- Related condition
- Reference range
<0.12 ug/L
- Units
- ug/L
- Synonyms
- Vitamin K epoxide
- Testing site
- Synnovis : Reference Services : Blackfriars Hub
- Laboratory
- Nutristasis Unit
- Sample type and volume required
- SST
- Call in advance
- No
- Special sample instructions
Protect from light.
- Storage and transport
- Sample must be protected from light, first class post
- Turnaround time
- 10 days
- Patient description
- Vitamin K1 2,3-epoxide is the bi-product of vitamin K1 formed when vitamin K is used as a cofactor in protein modification. Normally vitamin K epoxide is rapidly recycled by the enzyme vitamin K epoxide reductase (VKOR) and is not normally detectable in blood. If the action of the VKOR enzyme is blocked by vitamin K antagonist type anticoagulants such as warfarin or rodenticide superwarfarins vitamin K1 2,3-epoxide accumulates and becomes detectable in the blood. Vitamin K1 2,3- epoxide is measured by reversed phase HPLC with post column in-line chemical reduction and fluorescence detection.
- Contacts
Nutristasis Unit at Blackfriars Hub
Phone: 0204 591 0055
Email: Nutristasis@synnovis.co.uk
Nutristasis
Floor 1, Synnovis Hub
Friars Bridge Court
41-43 Blackfriars Road
London
SE1 8NZ