Unstable Haemoglobin screen
- Description
- Unstable haemoglobins are globin chain variants with defects affecting amino acid residues involved in the maintenance of steric shape and or subunit interaction. These internal changes can lead to altered oxygen affinity and increased sensitivity to denaturation, but are often silent on electrophoresis as they do not involve modifications to exterior charge. This assay uses isopropanol to facilitate the desnaturation and precipitation.
- Clinical details
- Haemolytic anaemia of variable severity
- Related condition
- Reference range
N/A
- Synonyms
- Unstable haemoglobin carrier
- Testing site
- Synnovis : Blood Sciences : Guy's Hospital
- Laboratory
- Flow Cytometry/ Immunophenotyping
- Sample type and volume required
- Whole Blood 4 mL (pediatric patients : 500ul-1000uL)
- Storage and transport
- Samples should be kept in fridge temperature and sent to laboratory as soon as possible
- Turnaround time
- 3 days Please contact laboratory to discuss urgent requests.
- Time limit for extra tests
- 7 days after sample collection
- Contacts
Flow Cytometry/Immunophenotyping Laboratory at Guy’s and St Thomas’ Clinical Advisory Service
Guy’s Hospital
Phone: 020 7188 2709 Monday – Friday 9:00 – 17:00
4th Floor – Southwark Wing
Great Maze Pond
London SE1 9RTSt Thomas’ Hospital
Phone: 020 7188 3421 Monday – Friday 09:00 – 17:00
5th Floor – North Wing
Westminster Bridge Road
London SE1 7EH