Anti-CCP (cyclic citrullinated peptide) is an essential initial investigation in those patients suspected of having rheumatoid arthritis (RA). It is highly specific for RA unlike rheumatoid factor (RF) which also occurs in other autoimmune disorders, chronic infections and in elderly individuals. Anti-CCP has prognostic significance for disease severity, radiographic erosions and early recognition of RA. While anti-CCP is of higher sensitivity and specificity than RF, they are independently informative in significant subsets of patients.
Related condition
Rheumatoid Arthritis
Reference range
<7
Units
u/ml
Testing site
Synnovis : Reference Services : Blackfriars Hub
Laboratory
Diagnostic Immunology
Sample type and volume required
Clotted (Gold top vacutainer)
Special sample instructions
All tests are compromised by long transit times. For this reason the date of bleed and of postage must be provided with each request.
Storage and transport
Serum stored at 4°C should be sent by first class post
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