Anti-Etanercept Antibodies (Free)
- Description
- The measurement of anti-Etanercept antibodies enables a greater understanding as to the underlying aetiology of treatment failure. Patients with detectable anti-Etanercept antibodies may be at risk of developing hypersensitivity reactions, particularly those being re-introduced after drug interruption. The detection of anti-Etanercept antibodies also guides management decisions on concomitant immunomodulation, dose escalation, drug switching and withdrawal. Measured as part of a profile including Etanercept levels.
- Clinical details
Due to the structure of the anti-TNFα drugs, the immune system may stimulate formation of antibodies against the drug (ADA, anti-drug antibodies). Antibody formation is associated with allergic reactions and loss of response due to neutralisation of biological effect and/or increased clearance of drug. Etanercept, being a fully humanised fusion protein, is thought to be less immunogenic than Infliximab.
- Related condition
- Reference range
Test interpretation requires full clinical information: drug dosage/frequency, previous exposure to other biologics, time of sampling, duration of therapy and clinical assessment. <5 ng/mL
- Units
ng/mL
- Testing site
- Synnovis : Reference Services : Blackfriars Hub
- Laboratory
- Precision Medicine
- Sample type and volume required
Serum (SST tube or plain) sample is preferred. Plasma (Lithium heparin, citrate or EDTA) is also acceptable. Minimum 300μL serum or plasma required for both drug and anti-drug antibody analysis.
- Call in advance
Please speak to the laboratory before requesting this test.
- Special sample instructions
Collect blood into a serum separation (SST™) or plain tube, preferably shortly before drug administration (trough levels). Centrifuge sample at 3000 rpm for 10 minutes, aliquot serum or plasma and keep in fridge until transport. If transport is going to be delayed by > 5 days, freeze at -20°C and send by first class post at a later date.
- Storage and transport
Post the sample to Synnovis Central Specimen Reception by first class post after speaking to the lab
- Turnaround time
Please contact the laboratory to discuss.
- Contacts
Precision Medicine Laboratory at Blackfriars Hub
Phone: 020 4 591 0058
Reference Chemistry
Floor 1, Synnovis hub
Friars Bridge Court
41-43 Blackfriars Road
London
SE1 8NZ